Kratom (KRA) is a tropical tree native to Southeast Asia, whose leaves contain psychoactive compounds like mitragynine and 7-hydroxymitragynine. Traditionally used for its stimulant effects at low doses and opioid-likese dative and analgesic properties at higher doses, it is often employed to manage pain, boost energy, or alleviate opioid withdrawal symptoms. Its legal status varies globally; while unscheduled in some regions, it is controlled or banned in others due to concerns about potential for dependence, abuse, and adulteration. Common side effects include nausea, constipation, and drowsiness, and serious adverse events like seizures and liver toxicity have been reported. More research is needed to fully understand its safety and therapeutic potential.

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