Prostate-Specific Antigen (PSA) is a protein produced by the prostate gland, with small amounts normally present in blood. The PSA blood test primarily screens for prostate cancer and monitors treatment response or recurrence. Elevated PSA levels can suggest prostate cancer but are also associated with benign conditions like benign prostatic hyperplasia (BPH) or prostatitis. While PSA testing is a key tool, it has limitations: it can produce false positives (leading to unnecessary biopsies) and false negatives (missing some cancers). Guidelines typically recommend informed decision-making for men aged 55-69, weighing potential benefits and harms with their healthcare provider.

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